About Staff： FY2005
NAKAGUCHI, Yoshitsugu (Researcher of Scientific Research)
Pathogenic Bacteriology
Research Interests
I am studying the relation between pathogenic bacteria and humans in Southeast
Asian countries. In particular, I currently focus on the dynamics of human
pathogenic bacteria like vibrios and Escherichia coli. Enteric infections
caused by pathogenic bacteria are recognized as serious diseases in these
areas. Recently, the incidence of Vibrio parahaemolyticus infection is
increasing worldwide. In 1996, a new pandemic clone had appeared in Southeast
Asian countries. And then, it spread out all over the world from these
areas. This new pandemic clone was discovered from international travelers
went through Southeast Asian countries. It is thought that it spread rapidly
to other countries by travelers or imported seafood. Accordingly, I hypothesize
that this spread of the infections can be caused by not only Vibrio parahaemolyticus
infection, but by other infections.
Key words: Pathogenic Bacteriology, Molecular Epidemiology, and Molecular
Genetics
Research Activities in 2005 Fiscal Year
- Publication
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- Patrick Guda BENJAMIN, Jurin Wolmon GUNSALAM, Son RADU, Suhaimi NAPIS,
Fatimah Abu BAKAR, Meting, BEON, Adom BENJAMIN, Clement, William DUMBA,
Selvanesan SENGOL, Faizul MANSUR, Rody JEFFREY, NAKAGUCHI Yoshitsugu and
NISHIBUCHI Mitsuaki (September 2005) “Factors Associated with Emergence
and Spread of Cholera Epidemics and its Control in Sarawak, Malaysia between
1994 and 2003”, Southeast Asian Studies, 43(2) 109-140.
- Yoshitsugu Nakaguchi and Mitsuaki Nishibuchi (2005), “The promoter region
rather than its downstream inverted repeat sequence is responsible for
low-level transcription of the thermostable direct hemolysin-related hemolysin
(trh) gene of Vibrio parahaemolyticus”, Journal of Bacteriology, 187(5)
1849-1855.
- Kanta Kurauchi, Yoshitsugu Nakaguchi, Makiko Tsutsumi, Hirosi Hori, Ryo
Kurihara, Shinya Hashimoto, Ryoko Ohnuma, Yoshikazu Yamamoto, Sumiko Mastuoka,
Shin’ichiro Kawai, Takashi Hirata, and Masato Kinoshita. (2005), “An in
vivo visual reporter system for detection of estrogen-like substances by
transgenic medaka” , Environmental Science & Technology, 39(8) 2762-2768.
- Jaime Martinez-Urtaza, Lourdes Simental, David Velasco, Angelo DePaola,
Masanori Ishibashi, Yoshitsugu Nakaguchi, Mitsuaki Nishibuchi, Dolores
Carrera-Flores, Carmen Rey-Alvarez, and Anxela Pousa (2005), “Pandemic
Vibrio parahaemolyticus O3:K6, Europe ”, Emerging Infectious Diseases 11(8)
1319-20.
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- Activity in Academic Association
-
- Academic Association：40th Annual Panel Meeting, United States - Japan Cooperative Medical Science
Program, Cholera & Other Bacterial Enteric Infections
- Topic：“Phylogeny and a Characteristic of the Pandemic Strains of Vibrio parahaemolyticus”
(Presenter)
- Place：Boston, Massachusetts, USA
- Term：November 30 - December 2, 2005
- Association：39th Vibrio parahaemolyticus Symposium
- Topic：“Variability of Vibrio parahaemolyticus strains isolated from the single
patients with diarrhea in southern Thailand” (Presenter)
- Place：Niigata, JAPAN
- Term：October 6 - 7, 2005
- Academic Association：39th Vibrio parahaemolyticus Symposium
- Topic：“Analysis of a character unique to the pandemic strains of Vibrio parahaemolyticus”
(Presenter)
- Place：Niigata, JAPAN
- Term：October 6 - 7, 2005
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