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"Infectious Diseases Spreading Across International Borders in Southeast Asia: The Elucidation of Area-Specific Features Based on Multifactorial Analysis"
Project Leader: NISHIBUCHI, Mitsuaki

• Outline
• Research Team

• Achievements

• Field Studies
• Seminars/Symposia/Workshops, etc.

• Publication :Books / Papers / Other Publications

• Lectures
• Presentations at Scientific Meetings
• Others

Outline

Important infectious diseases that spread across international borders and infect many people have long been known in Southeast Asia.  This indicates the measures to prevent the infections are not functioning in this area, and thus it is necessary to grasp the actual situation as precisely as possible and to elucidate the reasons.  Not only a microbiological factor (distribution of the pathogens in this area) but also many area-specific factors are related to occurrence and spread of the infectious diseases. Therefore, it is very important to clarify these factors and their interaction to help establish the measures against the infectious diseases.

We will carry out the study to clarify the rout of emerging enteric infections that spread across international borders and its chronology in the areas of Southeast Asia where the infection is prevalent or the pathogens are distributed, or in related areas.  In addition, we will study the transmission of malaria between Thailand and Myanmar and between Indonesia and Malaysia that is mediated by the migration of the labor and other people.  Furthermore, we will try to elucidate important factors that affect emergence and spread of the above infectious diseases including natural environments, life environments, cultural factors, social factors, economic factors, and political factors; and influence of emergence and spread of the infectious diseases on people’s life and society.  We will then summarize unique features of Southeast Asia.

Research Team

1. NISHIBUCHI, Mitsuaki (Professor, Center for Southeast Asian Studies, Kyoto University)
   
   Investigation on the spread of enteric infections, analysis of the factors in living environments, summary of the studies on enteric infections
2. KONO, Yasuyuki (Professor, Center for Southeast Asian Studies, Kyoto University)
   
   Analysis of the factors in natural environments and living environments
3. HAYAMI, Yoko (Professor, Center for Southeast Asian Studies, Kyoto University)
   
   Analysis of the effects of cultural factors, investigation on the effects on life and society
4. FUJITA, Koichi (Professor, Center for Southeast Asian Studies, Kyoto University)
   
   Analysis of the association with economic activities particularly in the area surrounding Southeast Asia
5. ISHIKAWA, Noboru (Associate Professor, Center for Southeast Asian Studies, Kyoto University)
   
   Investigation on the spread of malaria and summary of the malaria studies
6. OKAMOTO, Masaaki (Associate Professor, Center for Southeast Asian Studies, Kyoto University)
   
   Analysis of the systematic planning by the nations and international organizations
7. NAKAGUCHI, Yoshitsugu (Assistant Professor, Center for Southeast Asian Studies, Kyoto University)
   
   Investigation on the spread of enteric infections, analysis of the factors in living environments
8. IWADE, Yoshito (Department of Microbiology, Mie Prefecture Health and Environment Research Institute, Japan)
   
   Study on the prevention of food poisoning
9. ENDO, Tamaki （Lecturer, Faculty of Economics, Saitama University）
   
   Analysis of the association with economic activities particularly in the area surrounding Southeast Asia
10. WATANABE, Kazuya (Postdoctoral Research Associate, Center for Southeast Asian Studies, Kyoto University）
    
    Analysis of the factors in natural environments and living environments
11. MORISHITA, Akiko (Research Fellow, Graduate School of Asian and African Area Studies, Kyoto University)
    
    Analysis of the labor transfer between Indonesia and Malaysia
12. KOITABASHI, Tsutomu (Adviser, Asia Food Safety Research Center Inc./ Assistant General Manager, Qingdao CCIC-Chengyu Test of Food co., ltd.）
    
    Investigation on the spread of enteric infections
13. YOSHIKAWA, Minako Jen (PhD candidate, Graduate School of Asian and African Area Studies, Kyoto University)
    
    Analysis of the systematic planning on infectious diseases by the nations and international organizations
14. SHIMIZU, Rika　 (Graduate Student, Graduate School of Medicine, Kyoto University)
    
    Investigation on the spread of enteric infections
15. SHIMADA, Kanae (Graduate Student, Graduate School of Medicine, Kyoto University
    
    Investigation on the spread of enteric infections
16. RADU, Son (Professor, Faculty of Food Science and Biotechnology, University Putra Malaysia)
    
    Investigation on the spread of enteric infections among Indonesia, Malaysia, and Thailand
17. VUDDHAKUL, Varaporn (Associate Professor, Dept. of Microbiology, Fac. of Science, Prince of Songkla University, Thailand)
    
    Investigation on the spread of enteric infections between Thailand and Malaysia
18. MARLINA (Lecturer, Department of Pharmacy, Faculty of Mathematics and Natural Sciences, University of Andalas)
    
    Investigation on the spread of enteric infections between Indonesia and Malaysia
19. DJAMAL, Abdul Aziz (Associate Professor in Microbiology at the Faculty of Medicine, Andalas University; Head of Microbiology Installation Dr. M. Djamil General Hospital, Padang, Indonesia)
    
    Investigation on the spread of enteric infections in Indonesia

Achievements/ Field Studies

1. Term：June 6 - 13, 2007 (Research Report: PDF)
2. Research Areas：Sarawak, Malaysia
3. Researchers：Nishibuchi, M., Ishikawa, N., Nakaguchi, Y., Radu S., Benjamin, P. G., Apun, K.

1. Term：July 10 - 31, 2007
2. Research Area：Thailand
3. Researchers：Fujita, K., Endo, T.

1. Term：August 20 - 31, 2007 (Research Report: PDF)
2. Research Areas：Malaysia, Indonesia
3. Researchers：Nishibuchi, M., Nakaguchi, Y., Shimizu, R., Radu, S., Marlina

1. Term：September 6 - 8, 2007
2. Research Area：Thailand
3. Researcher：Hayami, Y.

1. Term：September 6, 2007
2. Research Area：Mie Prefecture, Japan
3. Researcher：Nishibuchi, M.

1. Term：September 21 - 24, 2007
2. Research Area：China (Research Report: PDF)
3. Researchers：Nishibuchi, M., Koitabashi, T.

1. Term：October 3 - 7, 2007
2. Research Area：Singapore （Research Report：PDF）
3. Researchers：Nishibuchi, M., Yoshikawa, M.J.

1. Term：October 8 - 20, 2007
2. Research Area：Thailand
3. Researchers：Yasuyuki Kono, Yoshitsugu Nakaguchi, Kazuya Watanabe

1. Term：October 20 - 28, 2007
2. Research Area：Thailand (Research Report: PDF)
3. Researchers：Mitsuaki Nishibuchi, Varaporn Vuddhakul

1. Term：December 15, 2007 – January 5, 2008
2. Research Area：China (Research Report: PDF)
3. Researcher：Koitabashi, T.

1. Term：January 21, 2008 – February 4, 2008
2. Research Area：China (Research Report: PDF)
3. Researcher：Koitabashi, T.

1. Term：February 18, 2008 – March 10, 2008
2. Research Area：China (Research Report: PDF)
3. Researcher：Koitabashi, T.

1. Term： February 27, 2008
2. Research Area：Visit to the Kansai Airport Quarantine Station (Research Report: PDF)
3. Researchers：Mitsuaki Nishibuchi, Minako Jen Yoshikawa, Rika Shimizu, and Kanae Shimada

1. Term： March 16 - 31, 2008
2. Research Areas：Singapore, Indonesia (Jakarta) (Research Report: PDF)
3. Researcher：Yoshikawa, M.J.

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Achievements/ Seminars, Symposia, Workshops

1. Date：August 23-24, 2007
2. Joint Workshop："Microbiological Risk Assessment Workshop"
3. Place：National Food Safety Research Center, Faculty of Food Science & Technology, University Putra Malaysia
4. Organizers：National Food Safety Research Center, Faculty of Food Science & Technology, University Putra Malaysia (Radu, S.) and Center for Southeast Asian Studies, Kyoto University (Nishibuchi, M., Nakagudhi, Y.).

1. Date：August 28 - 29, 2007
2. Joint Workshop："Application of Polymerase Chain Reaction (PCR) and DNA Techniques"
3. Place：Faculty of Mathematics and Natural Sciences, University of Andalas, Indonesia
4. Organizers： Department of Pharmacy, Faculty of Mathematics and Natural Sciences, University of Andalas (Marlina), National Food Safety Research Center, Faculty of Food Science & Technology, University Putra Malaysia (Radu, S.), and Center for Southeast Asian Studies, Kyoto University (Nishibuchi, M., Nakaguchi, Y.).

1. Date：August 29, 2007
2. International Seminar：" Application of Biomolecular to Industries and Health"
3. Place：University of Andalas, Indonesia
4. Organizers：University of Andalas (Purwati, E.), National Food Safety Research Center, Faculty of Food Science & Technology, University Putra Malaysia (Radu, S.), and Center for Southeast Asian Studies, Kyoto University (Nishibuchi, M., Nakaguchi, Y.).

1. Date：November 29, 2007
2. Seminar Name：Research Seminar for Nishibuchi Kakenhi Kiban (S)
3. Presenter：Hosono, Hiromi (Associate Professor, Graduate School of Agriculture, Kyoto University)
4. Title of Presentation：Development of Animal Hausbandary and Associated Public Health Issues in Vietnam

1. Date：March 11, 2008
2. Seminar Name：Research Seminar for Nishibuchi Kakenhi Kiban (S)
3. Presenter：Koitabashi, Tsutomu (Research Fellow, CSEAS, Kyoto University)
4. Title of Presentation：Safety of food from China (Abstract: PDF)

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Achievements/ Publications

Papers*“KAKENHI (191010)” is acknowledged.

1. Bhoopong, P., P. Palittapongarnpim, R. Pomwised, A. Kiatkittipong, M. Kamruzzaman, Y. Nakaguchi, M. Nishibuchi, M. Ishibashi, and V. Vuddhakul. 2007. Variability of the properties of Vibrio parahaemolyticus strains isolated from single patients. J. Clin. Microbiol. 45(5):1544-1550.

1. Marlina, S. Radu, C. Y. Kqueen, S. Napis, Z. Zakaria, S. A. Mutalib, and M. Nishibuchi. 2007. Detection of tdh and trh genes in Vibrio parahaemolyticus isolated from Corbicula molltkiana Prime in West Sumatera, Indonesia. Southeast Asian J. Trop. Med. Public Health 38(2):349-355.

1. Kalnauwakul, S., M. Phengmak, U. Kongmuang, Y. Nakaguchi, and M. Nishibuchi. 2007. Examination of diarrheal stools in Hat Yai City, southern Thailand, for Escherichia coli using immunomagnetic separation and PCR method. Southeast Asian J. Trop. Med. Public Health 38(5):871-850.

1. *Wootipoom, N. P. Bhoopong, R. Pomwised, M. Nishibuchi, M. Ishibashi, and V. Vuddhakul. 2007. A decrease in proportion of infections by pandemic Vibrio parahaemolyticus in Hat Yai Hospital, southern Thailand. J. Med. Microbiol. 56:1630-1638.

1. Matsuda, F., S. Ishimura, Y. Wagatsuma, T. Higashi, T. Hayashi, A. S. Faruque, D. A. Sack, and M. Nishibuchi. 2007. Prediction of epidemic cholera due to Vibrio cholerae O1 in children younger than 10 years using climate data in Bangladesh. Epidemiol. Infect. 136: 73-79.

1. Nishibuchi, M. Contamination of food by food-borne pathogens in Asia (Article in Japanese). SUNATEC e-Magazine　vol.018　　　2007/8/1. http://www.mac.or.jp/mail/070801/

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Achievements／Lectures

1. Date：May 10, 2007
2. Place：Tokyo, Japan
3. Theme：Environments and Food Safety in Asia (Special Lecture) in Japanese
4. Lecturer：Nishibuchi, M.
5. Meeting Name： Environments and Food Safety in Asia (in Japanese). The 93th Meeting of Food Hygienics Society of Japan.

1. Date：August 22, 2007
2. Place：Kuala Lumpur, Malaysia
3. Theme：Vibrio parahaemolyticus in Asia: infection and distribution in seafood.（Leading Speech)
4. Lecturer：Nishibuchi, M.
5. Conference Name：10th ASEAN Food Conference

1. Date：August 24, 2007
2. Place：Selangor, Malaysia
3. Theme：Microbiological risk assessment of Vibrio parahaemolyticus in bivalves in southern Thailand.
4. Lecturer：Nishibuchi, M.
5. Workshop Name：Microbiological Risk Assessment Workshop

1. Date：August 24, 2007
2. Place：Selangor, Malaysia
3. Theme： Application of the novel transcription-reverse transcription concerted (TRC) method for quantitative detection of specific mRNAs: detection of viable and virulent strains of Vibrio parahaemolyticus and Shiga toxin-producing Escherichia coli.
4. Lecturer：Nakaguchi, Y.
5. Workshop Name：Microbiological Risk Assessment Workshop

1. Date：August 28, 2007
2. Place：Padang, Indonesia
3. Theme：Application of polymerase chain reaction techniques to the study of infections by pathogenic Vibrio species.
4. Lecturer：Nishibuchi, M.
5. Workshop Name：Workshop on Application of Polymerase Chain Reaction (PCR) and DNA Techniques

1. Date：August 29, 2007
2. Place：Padang, Indonesia
3. Theme： Primer Design and its Application of PCR and Application of the Novel Transcription-reverse Transcription Concerted (TRC) Method for Quantitative Detection of Specific mRNAs in pathogenic Vibrio parahaemolyticus.
4. Lecturer：Nakaguchi, Y.
5. Workshop Name：Workshop on Application of Polymerase Chain Reaction (PCR) and DNA Techniques

1. Date：August 29, 2007
2. Place：Padang, Indonesia
3. Theme：Application of molecular genetics to the study of infectious diseases: examples of the studies on bacterial enteric pathogens in Asia.（Keynote lecture）
4. Lecturer：Nishibuchi, M.
5. Seminar Name：International Seminar on Application of Biomolecular to Industries and Health

1. Date：October 3, 2007
2. Place：Singapore
3. Theme： Difference in the concept of food safety among glocalizing Asian countries: lesson from international collaborative studies on enteric infections.（Invited lecture）
4. Lecturer：Nishibuchi, M.
5. Symposium Name：Symposium on Current & Innovative Approaches to Microbiological Food Safety Management (organized by International Commission on Microbiological Specifications for Foods)

1. Date：January 21, 2008
2. Place：Kuching, Malaysia
3. Theme： Escherichia coli O157 Carrying Shiga Toxin Gene 2 (stx2) but Producing no or Low-level Stx2 from Asian Countries.（Invited Speech)
4. Lecturer：Nishibuchi, M.
5. Seminar Name：Regional Symposium on Zoonosis and Emerging Infectious Diseases

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Achievements／Presentations at Scientific Meetings

1. Date：September 19, 2007
2. Place：Okayama, Japan
3. Presentation Topic：Analysis of pandemicity of the new clone of Vibrio parahaemolyticus causing pandemic spread of infections.
4. Presentesr：Nishioka, T., M. Kamruzzaman, K. Abe, Y. Satta, and M. Nishibuchi
5. Name of Scientific Meeting：The 79th Annual Meeting of the Genetics Society of Japan

1. Date：November 10, 2007
2. Place：Suita, Osaka, Japan
3. Presentation Topic：Detection of Shiga Toxin gene (stx)-bearing Escherichia coli in retail meats in China and characterization of O157-derived stx2 phages.
4. Presentesr：Kamruzzaman, M., T. Koitabashi, S. Cui, and M. Nishibuchi
5. Name of Scientific Meeting：The 60th Annual Meeting of the Kansai Branch of the Japanese Society for Bacteriology

1. Date：November 22, 2007
2. Place：Kobe, Japan
3. Presentation Topic：A functional insertion sequence, ISV 3L, mediated partial deletion of the tdh (thermostable direct hemolysin) gene inVibrio parahaemolyticus.
4. Presenters：Kamruzzaman, M., P. Bhoopong, V. Vuddhakul, and M. Nishibuchi
5. Name of Scientific Meeting：The 41th Vibrio parahaemolyticus　Symposium

1. Date：December 5, 2007
2. Place：Austin, Texas, U.S.A.
3. Presentation Topic： Distribution of Shiga Toxin gene (stx)-bearing Escherichia coli in retail meats in Qingdao, China and characterization of the stx2 phages from the E. coli O157 strains.
4. Presenters：Kamruzzaman, M., T. Koitabashi, S. Cui, and M. Nishibuchi
5. Name of Scientific Meeting：42nd Joint Conference on Cholera and Other Bacterial Enteric Infections Panel

1. Date：February 15, 2008
2. Place：Nakatou-gun, Okinawa Prefecture, Japan
3. Presentation Topic：An insertion sequence deletes the tdh (thermostable direct hemolysin) gene in Vibrio parahaemolyticus (PDF)
4. Presenters：Muhammad Kamruzzaman, Phuangthip Bhoopong, Varaporn Vuddhakul, and M. Nishibuchi
5. Name of Scientific Meeting：The 6th Kansensho [Infectious Diseases] Okinawa Forum

1. Date：March 24, 2008
2. Place：Kyoto, Japan
3. Presentation Topic：Genomic analysis of stx2 phages in stx2+ Escherichia coli O157 producing no or little Stx2
4. Presenters：Kamruzzaman, M., T. Koitabashi, and M. Nishibuchi
5. Name of Scientific Meeting：The 81st Annual Meeting of the Japanese Society for Bacteriology

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Achievements／Others

1. Newspaper Article
2. Name of Newspaper：Morning paper of The Yomiuri Shimbun
3. Article：Distribution of non-toxin-producing O157 in Asia: Kyoto University and collaborators “One of the reasons for low incidence of food poisoning cases” (article in Japanese)（PDF)
4. Interviewee ：Nishibuchi, M.
5. Date：December 29, 2007
6. URL：http://osaka.yomiuri.co.jp/edu_news/20071229kk01.htm

1. TV Interview
2. Program：Mainichi Broadcasting System (MBS) TV, NEWS23
3. Interviewee：Koitabashi, Tsutomu
4. Contents ：Food poisoning cases in Japan was suspected to be attributable to the insecticide (methamidophos) contained in the frozen dumpling produced in China. The interviewee explained the status of food safety in China. Image: JPG
5. Date：February 1, 2008

1. TV Interview
2. Program：NHK News 7
3. Interviewee：Koitabashi, Tsutomu
4. Contents ：Due to the concern over the insecticide (methamidophos)-bearing frozen dumplings produced in China, food safety situation in China was asked. The interviewee explained the status of food safety in China.
5. Date：March 10, 2008

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