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"Infectious Diseases Spreading Across International Borders in Southeast Asia: The Elucidation of Area-Specific Features Based on Multifactorial Analysis"
Project Leader: NISHIBUCHI, Mitsuaki

• Outline
• Research Team

• Achievements

• Field Studies
• Seminars/Symposia/Workshops, etc.

• Publication :Books / Papers / Other Publications

• Lectures
• Presentations at Scientific Meetings
• Others

Outline

Important infectious diseases that spread across international borders and infect many people have long been known in Southeast Asia.  This indicates the measures to prevent the infections are not functioning in this area, and thus it is necessary to grasp the actual situation as precisely as possible and to elucidate the reasons.  Not only a microbiological factor (distribution of the pathogens in this area) but also many area-specific factors are related to occurrence and spread of the infectious diseases. Therefore, it is very important to clarify these factors and their interaction to help establish the measures against the infectious diseases.

We will carry out the study to clarify the rout of emerging enteric infections that spread across international borders and its chronology in the areas of Southeast Asia where the infection is prevalent or the pathogens are distributed, or in related areas.  In addition, we will study the transmission of malaria between Thailand and Myanmar and between Indonesia and Malaysia that is mediated by the migration of the labor and other people.  Furthermore, we will try to elucidate important factors that affect emergence and spread of the above infectious diseases including natural environments, life environments, cultural factors, social factors, economic factors, and political factors; and influence of emergence and spread of the infectious diseases on people’s life and society.  We will then summarize unique features of Southeast Asia.

Research Team

1. NISHIBUCHI, Mitsuaki (Professor, Center for Southeast Asian Studies, Kyoto University)
   
   Investigation on the spread of enteric infections, analysis of the factors in living environments, summary of the studies on enteric infections
2. KONO, Yasuyuki (Professor, Center for Southeast Asian Studies, Kyoto University)
   
   Analysis of the factors in natural environments and living environments
3. HAYAMI, Yoko (Professor, Center for Southeast Asian Studies, Kyoto University)
   
   Analysis of the effects of cultural factors, investigation on the effects on life and society
4. FUJITA, Koichi (Professor, Center for Southeast Asian Studies, Kyoto University)
   
   Analysis of the association with economic activities particularly in the area surrounding Southeast Asia
5. ISHIKAWA, Noboru (Associate Professor, Center for Southeast Asian Studies, Kyoto University)
   
   Investigation on the spread of malaria and summary of the malaria studies
6. OKAMOTO, Masaaki (Associate Professor, Center for Southeast Asian Studies, Kyoto University)
   
   Analysis of the systematic planning by the nations and international organizations
7. NAKAGUCHI, Yoshitsugu (Assistant Professor, Center for Southeast Asian Studies, Kyoto University)
   
   Investigation on the spread of enteric infections, analysis of the factors in living environments
8. IWADE, Yoshito (Department of Microbiology, Mie Prefecture Health and Environment Research Institute, Japan)
   
   Study on the prevention of food poisoning
9. ENDO, Tamaki （Lecturer, Faculty of Economics, Saitama University）
   
   Analysis of the association with economic activities particularly in the area surrounding Southeast Asia
10. WATANABE, Kazuya (Postdoctoral Research Associate, Center for Southeast Asian Studies, Kyoto University）
    
    Analysis of the factors in natural environments and living environments
11. MORISHITA, Akiko (Research Fellow, Graduate School of Asian and African Area Studies, Kyoto University)
    
    Analysis of the labor transfer between Indonesia and Malaysia
12. KOITABASHI, Tsutomu (Adviser, Asia Food Safety Research Center Inc./ Assistant General Manager, Qingdao CCIC-Chengyu Test of Food co., ltd.）
    
    Investigation on the spread of enteric infections
13. YOSHIKAWA, Minako Jen (PhD candidate, Graduate School of Asian and African Area Studies, Kyoto University)
    
    Analysis of the systematic planning on infectious diseases by the nations and international organizations
14. SHIMIZU, Rika　 (Graduate Student, Graduate School of Medicine, Kyoto University)
    
    Investigation on the spread of enteric infections
15. SHIMADA, Kanae (Graduate Student, Graduate School of Medicine, Kyoto University
    
    Investigation on the spread of enteric infections
16. RADU, Son (Professor, Faculty of Food Science and Biotechnology, University Putra Malaysia)
    
    Investigation on the spread of enteric infections among Indonesia, Malaysia, and Thailand
17. VUDDHAKUL, Varaporn (Associate Professor, Dept. of Microbiology, Fac. of Science, Prince of Songkla University, Thailand)
    
    Investigation on the spread of enteric infections between Thailand and Malaysia
18. MARLINA (Lecturer, Department of Pharmacy, Faculty of Mathematics and Natural Sciences, University of Andalas)
    
    Investigation on the spread of enteric infections between Indonesia and Malaysia
19. DJAMAL, Abdul Aziz (Associate Professor in Microbiology at the Faculty of Medicine, Andalas University; Head of Microbiology Installation Dr. M. Djamil General Hospital, Padang, Indonesia)
    
    Investigation on the spread of enteric infections in Indonesia

Achievements/ Field Studies

1. Term：April 27, 2008 – May 2, 2008
2. Research Area：Southern Thailand (Research Report: PDF)
3. Researchers：Nishibuchi, M., Vuddhakul, V.

1. Term：May 5 - 9, 2008
2. Research Area：Singapore （Research Report: PDF）
3. Researcher：Yoshikawa, M.J.

1. Term：July 28 - August 23, 2008
2. Research Area：Padang (West Sumatera, Indonesia)
3. Researcher：Shimizu, R., A. Aziz Djamal

1. Term：September 1 - 15, 2008
2. Research Area：Singapore （Field Research Summary: PDF/ Report on JSPP21: PDF/ Report on NEA's Vector Control: PDF）
3. Researcher：Yoshikawa, M.J.

1. Term：September 8 - 19, 2008
2. Research Area：SuratThani Province, Thailand
3. Researcher：Kono, Y., Nakaguchi, Y., Watanabe, K.

1. Term：December 16 - 23, 2008
2. Research Area：Thailand
3. Researcher：Fujita, K.,Endo, T., Okamoto, I., Yamada, M.

1. Term：February 10-13, 2009 (Nishibuchi, M.)
2. Term：February 10-17, 2009 (Yoshikawa, M.J.)
3. Research Area：Hong Kong SAR, People’s Republic of China　（Summary Report: PDF）
4. Researcher：Nishibuchi, M and Yoshikawa, M.J.

1. Term：March 5-20, 2009
2. Research Area：Singapore（Summary Report: PDF）
3. Researcher：Yoshikawa, M.J.

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Achievements/ Seminars, Symposia, Workshops

1. Date：November 10, 2008
2. Seminar Name：Research Seminar for Nishibuchi Kakenhi Kiban (S)
3. Presenter：Balbir Singh　（Malaria Research Centre, Faculty of Medicine & Health Sciences, University Malaysia Sarawak, Kuching, Sarawak, Malaysia）
4. Title of Presentation：Malaria, Monkeys, Man & Malaysia (Abstract: PDF)

1. Date：November 12-13, 2008
2. Joint Workshop："Microbiological Risk Assessment Workshop"
3. Place：Center of Excellence for Food Safety Research, Faculty of Food Science & Technology, University Putra Malaysia
4. Organizers：Center of Excellence for Food Safety Research, Faculty of Food Science & Technology, University Putra Malaysia (Radu, S.) and Center for Southeast Asian Studies, Kyoto University (Nishibuchi, M.).
5. Presenter：Nishibuchi, M. (Report: PDF/ Flyer: PDF)
6. Cooperators：Yoshikawa, MJ., Shimizu, R.

1. Date：January 10, 2009
2. Saminar Name：Research Seminar for Nishibuchi Kakenhi Kiban (S)
3. Presenter：MA. LUCILA A. LAPAR　(International Livestock Research Institute, Vietnam）
4. Title of Presentation："Livestock Sector Development in Vietnam and Emerging Issues about Food Safety" (Abstract: PDF)
5. Presenter：Koji Seo (Faculty of Medicine, Kyoto University)
6. Title of Presentation："Investigation on the distribution of the pandemic strains of Vibrio parahaemolyticus in the molluscan shellfish marketed in Hat Yai City" southern Thailand"
7. Presenter：Rika Shimizu (Graduate School of Medicine, Kyoto University)　
8. Title of Presentation："Investigation on the infection by Vibrio parahaemolyticus in and around Padang City, Indonesia"
9. Presenter：Yoshikawa, M.J. (Graduate School of Asian and African Area Studies, Kyoto University)
10. Title of Presentation："Domestic Chikungunya fever outbreaks in Singapore: the control measures that reflect the political will of the city-state"

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Achievements/ Publications

Papers*“KAKENHI (191010)” is acknowledged.

1. *Muhammad, K., and M. Nishibuchi. 2008. Detection and characterization of a functional insertion sequence, ISVpa2, in Vibrio parahaemolyticus. Gene. 409: 92-99.

1. Nishibuchi, M., Y. Nakaguchi, T. Koitabashi. 2008. Hygienic conditions of environmental waters and food in Asia: evaluation of its relationship with people’s life using diarrhea as the indicator (Article in Japanese). Clean Technology. 18 (1): 50-53.

1. *Chai, L. C., A. B. Fatimah, F. M. Ghazali, H. Y. Lee, R. Tunung, A. T. Shamsinar, R. A. S. Laila, A. Z. Thahirahtul, P. M. Malakar, Y. Nakaguchi, M. Nishibuchi, and R. Son. 2008. Biosafety of Campylobacter jejuni from raw vegetables consumed as Ulam with reference to their resistance to antibiotics. Int. Food Res. J. 15(2):125-134.

1. *Koitabashi, T., S. Cui, K. Muhammad, and M. Nishibuchi. 2008. Isolation and characterization of the Shiga toxin gene (stx)-bearing Escherichia coli O157 and non-O157 from retail meats in Shandong Province, China and characterization of the O157-derived stx2 phages. J. Food Prot.71(4):706-713.

1. *Nishioka, T., M. Kamruzzaman, M. Nishibuchi, and Y. Satta. 2008. On the origin and function of an insertion element VPaI-1 specific to post-1995 pandemic Vibrio parahaemolyticus strains. Genes & Genetic Systems. 83(2):101-110.

1. Nishibuchi, M. 2008. Environments and Food Safety in Asia (article in Japanese). J. Food Hyg. Soc. Japan 48(6): J-414-416.

1. *Yamamoto, A., J. Iwahori, V. Vuddhakul, W. Charernjiratragulc, D. Vose, K. Osaka, M. Shigematsu, H. Toyofuku, S. Yamamoto, M. Nishibuchi, F. Kasuga. 2008. Quantitative modeling for risk assessment of Vibrio parahaemolyticus in bloody clams in southern Thailand. Int. J. Food Microbiol.124(1):70-78.

1. Y. Nakaguchi, T. Koitabashi, and M. Nishibuchi. 2008. Epidemiology of infections by vibrios: topics from overseas studies (Article in Japanese). Kagakuryoho-no-ryoiki (Antibiotics & Chemotherapy) 24(6):63-71.

1. Nishibuchi, M. 2008. Changes and the present status of food poisoning: variation of the causative factors and incidences and preventive measures. (Article in Japanese) Kagakuryoho-no-ryoiki (Antibiotics & Chemotherapy) 24(7):18-19.

1. Sugiyama, K., Y. Nakaguchi, andY. Kudo. 2008. Changes and present status of food poisoning due to Vibrio parahaemolyticus. (Article in Japanese) Kagakuryoho-no-ryoiki (Antibiotics & Chemotherapy) 24(7):57-66.

1. *Kamruzzaman, M., P. Bhoopong, V. Vuddhakul, and M. Nishibuchi. 2008. Detection of a functional insertion sequence responsible for deletion of the thermostable direct hemolysin gene (tdh) in Vibrio parahaemolyticus. Gene 421: 67-73.

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Achievements／Lectures

1. Date：October 17, 2008
2. Place：Seoul, Korea
3. Theme：Pandemic spread of the infection by a new clone of Vibrio parahaemolyticus from Asia.（Invited Speech)
4. Lecturer：Nishibuchi, M.
5. Seminar Name：The 9th Korea-Japan International Symposium on Microbiology

1. Date：November 12, 2008
2. Place：Selangor, Malaysia
3. Theme：Risk assessment of Vibrio parahaemolyticus in shellfish：an example of important microbiological risk assessment microbiological risk
4. Lecturer：Nishibuchi, M.
5. Seminar Name：Microbiological Risk Assessment Workshop：Quantitative Modeling for Microbial Risk Assessment (MRA)

1. Date：November 27, 2008
2. Place：Hokkaido University, Japan
3. Theme：Environmental and Social Factors and Risk of Infection (Invited Lecture) in Japanese
4. Lecturer：Nishibuchi, M.
5. Seminar Name：MMicrobiological Risk Derived from Environments – Real situation, Evaluation, and Near Future - (in Japanese). The Symposium of the 24th Meeting of Japanese Society of Microbial Ecology.

1. Date：December 20, 2008
2. Place：University of Tokyo, Japan
3. Theme：Pandemic Spread of the Infection by a New Clone of Vibrio parahaemolyticus and Safety of Fish and Shellfish (Invited Lecture) in Japanese
4. Lecturer：Nishibuchi, M.
5. Seminar Name：International Symposium on Food Safety and Food-borne Infectious Diseases.

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Achievements／Presentations at Scientific Meetings

1. Date：October 23, 2008
2. Place：Toyama, Japan
3. Presentation Topic： Toward application of the TRC method for detection of the mRNAs expressed from the toxin genes in viable Vibrio parahaemolyticus to examination of fish and shellfish
4. Presenters：Yoshitsugu Nakaguchi, and Mitsuaki Nishibuchi
5. Name of Scientific Meeting：The 42th Vibrio parahaemolyticus Symposium

1. Date：October 23, 2008
2. Place：Toyama, Japan
3. Presentation Topic：Investigation on the distribution of the pandemic strains of Vibrio parahaemolyticus in the molluscan shellfish marketed in Hat Yai City, southern Thailand
4. Presenters：Koji Seo, Pharanai Sukhumungoon, Varaporn Vuddhakul, Wataru Yamasaki, Yoshitsugu Nakaguchi, and Mitsuaki Nishibuchi
5. Name of Scientific Meeting：The 42th Vibrio parahaemolyticus Symposium

1. Date：October 23, 2008
2. Place：Toyama, Japan
3. Presentation Topic：Investigation on the infection by Vibrio parahaemolyticus in and around Padang City, Indonesia
4. Presenters：Rika Shimizu, A. Aziz. Djamal, Varaporn Vuddhakul, Koji Seo, Yoshitsugu Nakaguchi, and Mitsuaki Nishibuchi
5. Name of Scientific Meeting：The 42th Vibrio parahaemolyticus Symposium

1. Date：October 25, 2008
2. Place：Tokyo, Japan
3. Presentation Topic：Rapid containment of the first domestic Chikungunya fever outbreak in Singapore: the control measures that reflect the political will of the city-state (Abstract: PDF)
4. Presenters：Yoshikawa, M.J.and M. Nishibuchi
5. Name of Scientific Meeting：Joint Conference of The 49th Annual Meeting of Japanese Society of Tropical Medicine & The 23rd Annual Meeting of Japan Association for International Health

1. Date：November 17, 2008
2. Place：Fukuoka, Japan
3. Presentation Topic：Evaluation of combined use of probiotics, Bifidobacterium breve, on the immunogenicity of the oral, whole cell killed cholera vaccine in Bangladeshi children
4. Presenters：Fumiko Matsuda, Mohiul Islam Chowdhury, Amit Saha, Abdullah Al Tarique, Mitsuaki Nishibuchi, Firdausi Qadri
5. Name of Scientific Meeting：43ｒｄ Joint Conference on Cholera and Other Bacterial Enteric Infections Panel

1. Date：November 17, 2008
2. Place：Fukuoka, Japan
3. Presentation Topic：Detection in Southern Thailand of Shiga Toxin-producing Escherichia coli from the Beef Imported from Malaysia
4. Presenters：Pharanai Sukhumungoon, Rattanaruji Poomwised, Mitsuaki Nishibuchi, Natnicha Ingviya, Wilawan Charernjiratragul, Varaporn Vuddhakul
5. Name of Scientific Meeting：43ｒｄ Joint Conference on Cholera and Other Bacterial Enteric Infections Panel

1. Date：November 17, 2008
2. Place：Fukuoka, Japan
3. Presentation Topic：Prevalence of Vibrio vulnificus in Thai Seafood
4. Presenters：Rattanaruji Poomwised, Kanchana Srinitiworawong, Mitsuaki Nishibuchi, Varaporn Vuddhakul
5. Name of Scientific Meeting：43ｒｄ Joint Conference on Cholera and Other Bacterial Enteric Infections Panel

1. Date：March 12, 2009
2. Place：Nagoya, Japan
3. Presentation Topic：Molluscan shellfish trade is a route of pandemic spread of Vibrio parahaemolyticus infection
4. Presenters：Shimada, K., Sugiyama, A. Iwade, Y., Nakaguchi, Y., Nishibuchi, M.
5. Name of Scientific Meeting：The 82nd Annual Meeting of the Japanese Society for Bacteriology

1. Date：March 12, 2009
2. Place：Nagoya, Japan
3. Presentation Topic：Study on the quantitative detection method targeting the toxin-specific mRNA of Vibrio parahaemolyticus (in Japanese)
4. Presenters：Nakaguchi, Y. and M. Nishibuchi
5. Name of Scientific Meeting：The 82nd Annual Meeting of the Japanese Society for Bacteriology

1. Date：March 12, 2009
2. Place：Nagoya, Japan
3. Presentation Topic：Evaluation of the PCR methods for detection of a new clone of Vibrio parahaemolyticus and development of a new PCR method (in Japanese)
4. Presenters：Shimizu, R., Nakaguchi, Y., and M. Nishibuchi
5. Name of Scientific Meeting：The 82nd Annual Meeting of the Japanese Society for Bacteriology

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